Past T, Tapsonyi S, Jávor T
Pol J Pharmacol Pharm. 1984 Jul-Aug;36(4):401-6.
The developed physico-chemical panel system was tested by partly similar, partly different structures. The system seems to be useful with a high operating efficiency for the calculation and prediction of the absorption rates at different structures. One of the used physico-chemical molecular and system parameters seems to be particularly useful for characterisation of drug absorption. The authors propose the using of dipole moments for prediction of drug absorption, because this physico-chemical constant is calculable on the basis of chemical structures of drugs without measurements, and it characterizes the absorption rates with the largest probability from obtained physico-chemical constants in this panel system. The authors hope that this method will help in decreasing the costs and increasing the efficiency of drug-design.
所开发的物理化学面板系统通过部分相似、部分不同的结构进行了测试。该系统对于不同结构吸收速率的计算和预测似乎具有较高的运行效率且很有用。所使用的物理化学分子和系统参数之一对于药物吸收的表征似乎特别有用。作者建议使用偶极矩来预测药物吸收，因为这个物理化学常数可以根据药物的化学结构计算得出，无需测量，并且在该面板系统中，它最有可能从获得的物理化学常数中表征吸收速率。作者希望这种方法将有助于降低药物设计的成本并提高其效率。
