Puel J, Miquel J P, Massabuau P, Cassagneau B, Miluau S, Fauvel J M, Bounnoure J P
Rev Med Univ Navarra. 1984 Dec;28(4):43-6.
The author's experience on intracoronary thrombolysis on 71 patients that underwent coronary angiography in the first six hours of myocardial infarction is presented. The coronary artery responsible for the infarction was totally occluded in 66 cases and presented a subtotal occlusion in the remaining 5 cases. The protocol included the intracoronary injection of 2 mg isosorbide dinitrate and 78.000-385.000 U of streptokinase. An early reperfusion occurred in 66% of the patients, without mortality in the acute phase. ST-segment returned to normal in 41 of the 47 reperfused cases, but a Q wave developed in 42 cases. Hospital mortality was 6,4%, and the reocclusion rate was 17%.
本文介绍了作者对71例在心肌梗死最初6小时内接受冠状动脉造影的患者进行冠状动脉内溶栓的经验。导致梗死的冠状动脉在66例中完全闭塞，其余5例为次全闭塞。治疗方案包括冠状动脉内注射2mg硝酸异山梨酯和78000 - 385000U链激酶。66%的患者出现早期再灌注，急性期无死亡病例。47例再灌注病例中有41例ST段恢复正常，但42例出现Q波。住院死亡率为6.4%，再闭塞率为17%。
