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训练后海马内注射氧化震颤素对亮度辨别巩固的影响。

Influence of post-training intrahippocampally applied oxotremorine on the consolidation of a brightness discrimination.

作者信息

Grecksch G, Ott T, Matthies H

出版信息

Pharmacol Biochem Behav. 1978 Mar;8(3):215-8. doi: 10.1016/0091-3057(78)90307-6.

DOI:10.1016/0091-3057(78)90307-6
PMID:652831
Abstract

The posttraining intrahippocampal injection of oxotremorine revealed an improvement of the retention performance in a brightness discrimination task. The oxotremorine effect seemed to be dependent on distinct variables of training and was restricted to rats exhibiting a good acquisition performance. Scopolamine impaired the retention performance of animals with few training errors. The role of hippocampal cholinergic synapses for consolidation was discussed.

摘要

训练后向海马体内注射氧化震颤素,结果显示在亮度辨别任务中记忆保持能力有所改善。氧化震颤素的效果似乎取决于训练的不同变量,并且仅限于在习得表现良好的大鼠中出现。东莨菪碱损害了训练错误较少的动物的记忆保持能力。文中讨论了海马胆碱能突触在巩固过程中的作用。

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