[Calcium-dependent regulation of NAD-isocitrate dehydrogenase in the rat heart mitochondria].
作者信息
Larionov N P, Kolykhalova I V
出版信息
Vopr Med Khim. 1984 Sep-Oct;30(5):87-9.
PMID:6528524
Abstract
Ions of Ca2+ (0.1-20 mumoles) regulated the activity of mitochondrial NAD-isocitrate dehydrogenase (isocitrate: NAD-oxidoreductase decarboxylating, EC 1.1.1.41) from rat heart altering the enzyme affinity for isocitrate. Under conditions of maximal activation by Ca2+ (20 mumoles) S0,5 was decreased from 282 down to 125 mumoles, Vmax was not altered. The calmodulin inhibitor trifluoperazine did not affect the Vmax, S0.5 and the Hill coefficient of the enzyme.
摘要
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