Muss H B, Bundy B, DiSaia P J, Stehman F B, Beecham J
Am J Clin Oncol. 1984 Dec;7(6):741-4. doi: 10.1097/00000421-198412000-00027.
Thirty-six patients with advanced carcinoma of the cervix received PALA at a dosage of 5 gm/m2 every three weeks. Thirty-three patients had received prior irradiation therapy and chemotherapy. No complete or partial responses were seen. The major toxicity was dermatologic and occurred in 16/36 (44%) of patients. Three patients experienced dose limiting disorientation or confusion. PALA was not associated with any antitumor activity in patients with advanced carcinoma of the cervix who had received prior chemotherapy. The results of this study indicate that PALA has no substantial activity in patients with advanced squamous carcinoma of the cervix who have previously received chemotherapy.
36例晚期宫颈癌患者接受了丙氨酸-氨基异丁酸（PALA）治疗，剂量为每三周5克/平方米。33例患者此前接受过放疗和化疗。未观察到完全缓解或部分缓解。主要毒性为皮肤毒性，16/36（44%）的患者出现该毒性。3例患者出现剂量限制性定向障碍或意识模糊。对于先前接受过化疗的晚期宫颈癌患者，PALA未显示出任何抗肿瘤活性。本研究结果表明，PALA对先前接受过化疗的晚期宫颈鳞状细胞癌患者无显著活性。
