Blancou J, Pépin M, Soulebot J P, Brun A
Ann Rech Vet. 1984;15(4):543-7.
The kinetics and the titre of the serum neutralising antibodies have been studied for 55 months, in eight cows already vaccinated against rabies with a commercial vaccine. The titres remained stable during this period and increased after the booster injection 16 months after the primary immunization. The protection obtained with this vaccine was tested. These cattle and five controls were inoculated in each masseter muscle in the 55th month with a street rabies virus suspension (5 x 10(5) MICLD50). None or very low serum neutralising antibody titres were found among the controls. However, the inoculation of street rabies virus elicited an irregular immune response among the vaccinated cows. All the controls died whereas all the cows which had received one booster injection survived.
对8头已用商业疫苗接种狂犬病疫苗的奶牛，研究了血清中和抗体的动力学和效价，为期55个月。在此期间，效价保持稳定，并在初次免疫后16个月进行加强注射后有所增加。对该疫苗所提供的保护作用进行了测试。在第55个月时，给这些牛和5头对照牛的每侧咬肌接种了街狂犬病毒悬液（5×10⁵最小感染量半数致死量）。对照牛中未发现或仅发现非常低的血清中和抗体效价。然而，接种街狂犬病毒在接种疫苗的奶牛中引发了不规则的免疫反应。所有对照牛均死亡，而所有接受一次加强注射的奶牛均存活。
