Friedman M J, Stolk J M
Psychosom Med. 1978 Mar;40(2):107-15. doi: 10.1097/00006842-197803000-00003.
Serum dopamine-beta-hydroxylase (DBH) activity was measured in a heterogeneous sample of 290 outpatients awaiting medical, surgical, or psychiatric appointments at a Veterans Administration Hospital. All patients were assessed for depressive symptomatology by the Zung Self-Rating Depression Scale (SDS) and for elevated diastolic blood pressure (BP greater than or equal to 90 mm Hg). Elevated DBH activity was associated with SDS scores greater than or equal to 60. No statistical association was found between DBH activity and diastolic BP. Two pharmacological agents, alpha-methyl-DOPA and minor tranquilizers, also were associated with significant alterations in serum DBH activity.
在一家退伍军人管理局医院，对290名等待内科、外科或精神科预约的门诊患者的异质样本进行了血清多巴胺-β-羟化酶（DBH）活性检测。所有患者均通过zung自评抑郁量表（SDS）评估抑郁症状，并测量舒张压升高情况（血压大于或等于90毫米汞柱）。DBH活性升高与SDS评分大于或等于60相关。未发现DBH活性与舒张压之间存在统计学关联。两种药物，α-甲基多巴和小剂量镇静剂，也与血清DBH活性的显著变化有关。
