Huttunen J K, Pispa J, Kumlin T, Mattila S, Naukkarinen V, Miettinen T
Hypertension. 1979 Jan-Feb;1(1):47-52. doi: 10.1161/01.hyp.1.1.47.
The activity of serum dopamine-beta-hydroxylase (DBH) was measured in 1194 asymptomatic middle-aged men with diastolic blood pressure ranging from 75 to 125 mm Hg during the baseline examination of a multifactorial intervention program for primary prevention of coronary heart disease. No correlation was present between serum DBH activity and systolic (r = -0.01, NS) or diastolic (r = +0.02, NS) blood pressure. No significant differences in serum DBH activity was observed between individuals with blood pressure in the lower, middle or upper deciles. Serum DBH activity was similar in subjects with normal blood pressure, in individuals with widely fluctuating blood pressure and in patients with fixed hypertension. The results suggest that serum DBH activity cannot be used as an aid in the diagnosis of essential hypertension of middle-aged men.
在一项针对冠心病一级预防的多因素干预项目的基线检查中，对1194名无症状中年男性进行了血清多巴胺-β-羟化酶（DBH）活性检测，这些男性的舒张压在75至125毫米汞柱之间。血清DBH活性与收缩压（r = -0.01，无显著性差异）或舒张压（r = +0.02，无显著性差异）之间无相关性。在血压处于低、中、上十分位数的个体之间，未观察到血清DBH活性有显著差异。血压正常的受试者、血压波动较大的个体以及持续性高血压患者的血清DBH活性相似。结果表明，血清DBH活性不能用于辅助诊断中年男性的原发性高血压。
