Rateau J G, Devaux A
Ann Gastroenterol Hepatol (Paris). 1984 Mar-Apr;20(2):65-70.
The stomach wall is protected by its own secretion of mucus. The superficial layer consist of a parietal film of acid mucus, adhering to the epithelium. The acid mucus reach its maximum viscosity at pH 5. We investigate, in the rat, the interaction between this mucus with a montmorillonite, a kind of clay, known to have a mucoprotective effect, and with the association of montmorillonite and an antiacid drug. Three hours after ingestion the clay particles saturated the parietal mucus, then, up to the sixth hour their abondance decrease. The parietal film of mucus is abundant until the sixth hour, this data confirm the protection of the gastric mucosa by this drugs association.
胃壁受到其自身分泌的黏液的保护。表层由一层酸性黏液的壁膜组成，附着在上皮细胞上。酸性黏液在pH值为5时达到最大黏度。我们在大鼠身上研究了这种黏液与蒙脱石（一种已知具有黏膜保护作用的黏土）以及蒙脱石与抗酸药物联合使用之间的相互作用。摄入三小时后，黏土颗粒使壁膜黏液饱和，然后，直到第六小时其含量减少。黏液壁膜在第六小时前都很丰富，这些数据证实了这种药物联合使用对胃黏膜的保护作用。
