Vincent J L, Dufaye P, Berre J, Kahn R J
Am J Emerg Med. 1984 Nov;2(6):504-6. doi: 10.1016/0735-6757(84)90074-3.
Bretylium has been well-recognized as an effective antiarrhythmic agent for acute ventricular arrhythmias, but its use is believed to be contraindicated in digitalis intoxication. We report of two patients in whom digitalis-induced malignant ventricular arrhythmias were refractory to lidocaine. One patient had had repeated episodes of ventricular fibrillation associated with digitoxin and quinidine intoxication, and one patient had had malignant premature ventricular beats associated with digoxin intoxication. Cardiac electrical activity was paced in both instances. In the two patients, ventricular arrhythmias rapidly resolved, and no side effect was encountered. These observations support the administration of bretylium for severe digitalis-induced ventricular arrhythmias.
溴苄铵已被公认为是治疗急性室性心律失常的有效抗心律失常药物，但人们认为在洋地黄中毒时使用该药是禁忌的。我们报告了两例洋地黄所致恶性室性心律失常对利多卡因治疗无效的患者。一例患者曾反复发生与洋地黄毒苷和奎尼丁中毒相关的室颤，另一例患者曾发生与地高辛中毒相关的恶性室性早搏。在这两例患者中均进行了心脏电起搏。两例患者的室性心律失常均迅速得到缓解，且未出现副作用。这些观察结果支持将溴苄铵用于治疗严重的洋地黄所致室性心律失常。
