Wilson B A, Eldridge F L, Millhorn D E, Waldrop T G, Klingler L E
Brain Res. 1984 Dec 24;324(2):366-8. doi: 10.1016/0006-8993(84)90051-9.
The present study examined the effect on respiration of naloxone administered centrally. Experiments were performed on anesthetized, paralyzed cats whose vagi and carotid sinus nerves had been cut. The animals' end-tidal pCO2 and body temperature were kept constant with servocontrollers. Naloxone administered into the third cerebral ventricle in doses of 40 micrograms/kg and 400 micrograms/kg resulted in significant (P less than 0.05) increases in phrenic neural activity. The response to the 400 micrograms/kg dose was significantly greater (P less than 0.05) than the response to the 40 micrograms/kg dose. A dose of 40 micrograms/kg naltrexone administered to each of two animals produced similar increases in respiratory activity. These data indicate that in the preparation studied endogenous opiates exert a tonic inhibitory effect on respiration through their action on central opiate receptors.
本研究检测了中枢给予纳洛酮对呼吸的影响。实验在麻醉、麻痹且迷走神经和颈动脉窦神经已被切断的猫身上进行。动物的呼气末二氧化碳分压和体温通过伺服控制器保持恒定。以40微克/千克和400微克/千克的剂量向第三脑室注射纳洛酮导致膈神经活动显著（P<0.05）增加。对400微克/千克剂量的反应显著大于（P<0.05）对40微克/千克剂量的反应。给两只动物各注射40微克/千克的纳曲酮剂量后，呼吸活动出现了类似的增加。这些数据表明，在所研究的制备中，内源性阿片类物质通过其对中枢阿片受体的作用对呼吸发挥了紧张性抑制作用。
