Cumming M E, Ong B Y, Wade J G, Sitar D S
Can J Physiol Pharmacol. 1984 Dec;62(12):1435-9. doi: 10.1139/y84-238.
The disposition and cardiovascular effects of ethanol were studied in near-term pregnant sheep and their fetuses after intravenous infusions either to the mother or the fetus. Placental transfer of ethanol from mother to fetus was rapid, but transfer from the fetal to maternal circulation was impaired when ethanol was administered directly to the fetus. Plasma clearance of ethanol was similar from the mother and fetus in utero. In the maternal infusion experiments, both maternal and fetal heart rate increased with plasma ethanol concentration. However, in the fetal infusion experiments, both maternal and fetal heart rate increased with plasma ethanol concentration. However, in the fetal infusion experiments, fetal heart rate was inversely related to plasma ethanol concentrations while maternal mean arterial blood pressure increased with maternal plasma ethanol concentration. Further studies in neonatal lambs are needed to determine if ethanol has adverse effects on hemodynamics when the neonate is separated from its protective intrauterine environment.
在临近足月的怀孕绵羊及其胎儿中，研究了乙醇经静脉输注给母体或胎儿后的处置情况及其对心血管系统的影响。乙醇从母体到胎儿的胎盘转运迅速，但当直接给胎儿输注乙醇时，从胎儿到母体循环的转运受到损害。子宫内母体和胎儿的乙醇血浆清除率相似。在母体输注实验中，母体和胎儿心率均随血浆乙醇浓度升高而增加。然而，在胎儿输注实验中，虽然母体和胎儿心率也随血浆乙醇浓度升高而增加，但胎儿心率与血浆乙醇浓度呈负相关，而母体平均动脉血压随母体血浆乙醇浓度升高而增加。需要对新生羔羊进行进一步研究，以确定当新生儿与其保护性的子宫内环境分离时，乙醇是否会对血流动力学产生不利影响。
