Romics I, Lengyel L
Eur Urol. 1984;10(6):395-7. doi: 10.1159/000463842.
The serum and urine hydroxyproline levels of patients with prostatic cancer were regularly studied for 30 months. Bone metastases were found in 4 patients at the beginning of the study; metastases formed in 8 patients during the test period, and in 9 patients no metastases formed during the study. At the time of X-ray diagnosis of metastasis, significantly higher serum and urine hydroxyproline levels and enzymatic phosphatase were found, but in the tests performed 3 months earlier, in spite of the negative X-ray results, the hydroxyproline results differed significantly from the reference values. The above findings support the use of the hydroxyproline test for the diagnosis of metastases.
对前列腺癌患者的血清和尿液羟脯氨酸水平进行了为期30个月的定期研究。研究开始时在4例患者中发现骨转移；在测试期间有8例患者出现转移，9例患者在研究期间未出现转移。在X线诊断转移时，发现血清和尿液羟脯氨酸水平及酶性磷酸酶显著升高，但在3个月前进行的检测中，尽管X线结果为阴性，但羟脯氨酸结果与参考值有显著差异。上述发现支持使用羟脯氨酸检测来诊断转移。
