Friedman R L, Sanders-Bush E, Barrett R L
Eur J Pharmacol. 1984 Oct 30;106(1):191-3. doi: 10.1016/0014-2999(84)90695-2.
Clozapine was tested in two serotonin-dependent behavioral measures. One group of rats was trained to discriminate the serotonin agonist, quipazine, from saline in a two-lever operant choice task. Pretreatment with clozapine completely blocked the discrimination of quipazine. Another group of rats was trained to bar press for milk on a variable interval schedule of reinforcement. Quipazine decreased the response rate in these animals and pretreatment with clozapine completely reversed this effect. Thus, clozapine acted as a serotonin antagonist in both measures of serotonin function.
氯氮平在两项依赖血清素的行为测试中接受了检验。一组大鼠在双杠杆操作性选择任务中接受训练，以区分血清素激动剂喹哌嗪和生理盐水。用氯氮平进行预处理完全阻断了对喹哌嗪的辨别。另一组大鼠在可变间隔强化程序下接受训练，通过按压杠杆获取牛奶。喹哌嗪降低了这些动物的反应率，而用氯氮平进行预处理则完全逆转了这种效应。因此，在血清素功能的两项测试中，氯氮平均表现为血清素拮抗剂。
