Watson M L, McCormick J, Ungar A
J Hypertens. 1984 Oct;2(5):479-83. doi: 10.1097/00004872-198410000-00006.
During established two-kidney one clip hypertension in dogs blood pressure is elevated despite only slightly raised plasma renin activity. Dose dependent effects of exogenous angiotensin II on systemic and renal haemodynamics were examined before and after induction of this type of hypertension in conscious dogs. There was no difference in the response of blood pressure to angiotensin II in each group, suggesting that altered pressor sensitivity to angiotensin II is not the cause of the persisting hypertension. However sodium excretion, effective renal plasma flow and glomerular filtration rate were all decreased by angiotensin II in the normotensive group, but were unchanged or increased in the hypertensive group. Renal prostaglandin E excretion was also increased in the hypertensive animals, and further increased during infusion with angiotensin II. The altered renal response to angiotensin II in the hypertensive group may reflect changes in occupancy of angiotensin II receptors and/or enhanced renal release of vasodilator prostaglandins.
在犬双侧肾动脉狭窄一侧夹闭造成的高血压形成过程中，尽管血浆肾素活性仅略有升高，但血压仍会升高。在清醒犬诱导此类高血压之前和之后，研究了外源性血管紧张素II对全身和肾脏血流动力学的剂量依赖性影响。每组中血压对血管紧张素II的反应没有差异，这表明对血管紧张素II的升压敏感性改变不是持续性高血压的原因。然而，在正常血压组中，血管紧张素II会降低钠排泄、有效肾血浆流量和肾小球滤过率，但在高血压组中这些指标未发生变化或有所增加。高血压动物的肾脏前列腺素E排泄也增加，在输注血管紧张素II期间进一步增加。高血压组中肾脏对血管紧张素II的反应改变可能反映了血管紧张素II受体占有率的变化和/或肾脏血管舒张性前列腺素释放的增强。
