Stalenhoef A F, van Niekerk J L, Demacker P N, van 't Laar A
J Lipid Res. 1984 Dec 1;25(12):1350-7.
Partial ileal bypass surgery in homozygous Watanabe heritable hyperlipidemic (WHHL) rabbits resulted in a decrease of low density lipoproteins (LDL)-cholesterol from 14.2 +/- 2.4 to 7.0 +/- 1.2 mmol/l. To investigate the effect of partial ileal bypass on receptor-mediated and receptor-independent LDL catabolism, turnover studies were performed of radiolabeled native LDL and chemically modified LDL (methyl-LDL) in WHHL rabbits after partial ileal bypass, in WHHL control rabbits, and in New Zealand White ("normal") rabbits. The plasma LDL pool in WHHL control rabbits was increased 10-fold. The receptor-mediated LDL clearance was essentially zero in WHHL rabbits, both in controls and after ileal bypass surgery; the fractional catabolic rates for total LDL were equal in both WHHL groups and were also similar to that for methyl-LDL in the normal rabbits. Seventy percent of the total LDL clearance in the normal rabbits occurred via the LDL receptor pathway. In the animals with a partial ileal bypass, the plasma LDL-protein pool was appreciably lower than in WHHL controls (41.6 +/- 5.7 vs 73.4 +/- 9.9 mg/kg, P less than 0.02). The absolute catabolic rate was almost 50% lower in the PIB group (21.4 +/- 2.0 vs 40.0 +/- 7.5 mg X kg-1 X day-1, P less than 0.02). These results indicate that the decrease of LDL after partial ileal bypass surgery in WHHL rabbits is the result of a reduced production rate of LDL.
对纯合子渡边遗传性高脂血症（WHHL）兔进行部分回肠旁路手术后，低密度脂蛋白（LDL）胆固醇从14.2±2.4降至7.0±1.2 mmol/l。为研究部分回肠旁路对受体介导和非受体依赖性LDL分解代谢的影响，在部分回肠旁路手术后的WHHL兔、WHHL对照兔和新西兰白兔（“正常”兔）中进行了放射性标记的天然LDL和化学修饰LDL（甲基化LDL）的周转研究。WHHL对照兔的血浆LDL池增加了10倍。在WHHL兔中，无论是对照还是回肠旁路手术后，受体介导的LDL清除率基本为零；两个WHHL组中总LDL的分解代谢率相等，且也与正常兔中甲基化LDL的分解代谢率相似。正常兔中70%的总LDL清除通过LDL受体途径发生。在进行部分回肠旁路手术的动物中，血浆LDL蛋白池明显低于WHHL对照兔（41.6±5.7 vs 73.4±9.9 mg/kg，P<0.02）。PIB组的绝对分解代谢率几乎低50%（21.4±2.0 vs 40.0±7.5 mg·kg-1·d-1，P<0.02）。这些结果表明，WHHL兔部分回肠旁路手术后LDL的降低是LDL产生率降低的结果。
