两例婴儿因服用双环胺致死。血液中治疗浓度和中毒浓度的测定。

Two cases of death involving dicyclomine in infants. Measurement of therapeutic and toxic concentrations in blood.

作者信息

Garriott J C, Rodriquez R, Norton L E

出版信息

J Toxicol Clin Toxicol. 1984;22(5):455-62. doi: 10.3109/15563658408992576.

Abstract

In two deaths of infants investigated by the Medical Examiner, high levels of dicyclomine were detected in blood. In one of the cases, a level of 0.505 micrograms/ml was found, nearly 10 times reported adult therapeutic blood concentrations, and death was ascribed to an overdose of dicyclomine. Gas chromatography/mass spectrometry was used for the analysis of biological specimens.

摘要

在法医调查的两起婴儿死亡事件中，血液中检测到了高浓度的双环胺。其中一个案例中，检测到的浓度为0.505微克/毫升，几乎是报告的成人治疗性血液浓度的10倍，死亡原因被认定为双环胺过量。采用气相色谱/质谱法对生物样本进行分析。