Woodhouse N J, Hoare A, Mohamedally S M, Marsden P
Horm Res. 1976;7(4-5):238-46. doi: 10.1159/000178734.
Four patients with thyrotoxicosis, hypercalcaemia and metabolic bone disease are described. One of them had a 'hot nodule', T3 toxicosis and a parathyroid tumour and another had thin bones, subperiosteal cortical bone erosions and complete dysphagia. Hypercalcaemia persisted during treatment with antithyroid drugs in two patients, both of whom had hyperparathyroidism. The administration of salmon calcitonin to these two patients before starting antithyroid treatment produced an immediate and sustained fall in serum calcium and urinary hydroxyproline levels. Calcitonin administration should be of value in the early management of hypercalcaemic patients.
本文描述了4例患有甲状腺毒症、高钙血症和代谢性骨病的患者。其中1例有“热结节”、T3型甲状腺毒症和甲状旁腺肿瘤，另1例有骨质稀疏、骨膜下皮质骨侵蚀和完全性吞咽困难。2例患有甲状旁腺功能亢进的患者在接受抗甲状腺药物治疗期间高钙血症持续存在。在开始抗甲状腺治疗前，给这2例患者使用鲑鱼降钙素后，血清钙和尿羟脯氨酸水平立即且持续下降。降钙素治疗在高钙血症患者的早期管理中应具有重要价值。
