[呋喃妥因在怀孕大鼠体内的药代动力学]
[Pharmacokinetics of nitrofurantoin in the bodies of pregnant rats].
作者信息
Wierzba K, Wańkowicz B, Prokopczyk J, Piekarczyk A
出版信息
Probl Med Wieku Rozwoj. 1984;13:185-92.
The investigation of nitrofurantoin (NTF) pharmacokinetics in pregnant rats was undertaken to estimate its cumulation in the fetus unit. It was found that pharmacokinetics of NTF is dose-dependent in non-pregnant rats. The biological half-life time increased from 0.24 to 0.41 and 0.72 h for NTF doses 10.20 and 40 mg/kg, respectively. The elimination of NTF was diminished in pregnant rats. The pharmacokinetic analysis revealed a possibility of strong NTF accumulation in the pregnant rats (increased K12/K21 ratio). Taking into account increased renal function in pregnancy, one may suspect that decreased elimination of NTF was rather caused by its significant cumulation in the changed tissue compartment.
为评估呋喃妥因（NTF）在胎儿体内的蓄积情况，对妊娠大鼠进行了NTF药代动力学研究。研究发现，NTF在非妊娠大鼠中的药代动力学呈剂量依赖性。NTF剂量分别为10、20和40 mg/kg时，其生物半衰期从0.24小时增加至0.41小时和0.72小时。妊娠大鼠中NTF的消除减少。药代动力学分析显示，NTF在妊娠大鼠中可能有强烈的蓄积（K12/K21比值增加）。考虑到孕期肾功能增强，人们可能怀疑NTF消除减少主要是由于其在变化的组织隔室中显著蓄积所致。
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