用于定量描述药物制剂从软膏基质中体外释放的简单数学函数的应用。
Application of the simple mathematical function for the quantitative description of in vitro release of drug agents from the ointment bases.
作者信息
Bialik W
出版信息
Pharmazie. 1984 Nov;39(11):763-4.
PMID:6531381
Abstract
An attempt of the quantitative description of the release process by the simple mathematical functions has been made. It was found that the hyperbolic function q = t/(A + Bt) is the best for this application. The values of the parameters 1/A and 1/B are proportional to the released amounts of drug, so they can be useful for the evaluation of the rate of the release process.
摘要
已尝试用简单数学函数对释放过程进行定量描述。结果发现，双曲线函数q = t/(A + Bt)最适用于此应用。参数1/A和1/B的值与药物释放量成正比，因此它们可用于评估释放过程的速率。
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