Studies of the substructures of the lysozyme-rich secretory granule of the serous cell in the human nasal gland.

Using a protein A-gold immunohistochemical technique, the lysozyme rich core and the lysozyme free peripheral rim were differentiated in the secretory granule of the serous cell in the human nasal mucosa, under the electronmicroscope. The shperical lysozyme rich core, which had been excreted into the gland lumen, was also wrapped with the peripheral rim. This finding suggests that the peripheral rim defends the integrity of the core and inhibits the release of lysozyme from the core.