Ishiwata H, Iwata R, Tanimura A
IARC Sci Publ. 1984(57):255-60.
The dimethylamine (DMA) concentration in the gastrointestinal tract of Wistar male rats fed a commercial diet containing 23.6 mg/kg DMA was highest (11.2 +/- 2.1 mg/kg) in the stomach and decreased from the upper region to the lower region. In contrast, the highest DMA concentration (6.6 +/- 2.5 mg/kg) in the upper small intestine was observed in rats fed a low-DMA diet containing 1.0 mg/kg DMA. DMA absorption was observed in the intestines and the absorbtion curves were monoexponential. The biological half-lives (t1/2) of DMA in the ligated stomach, upper and lower small intestine, caecum and large intestine were 198, 8.3, 11.6, 31.5 and 11.0 min, respectively. The DMA concentration in blood increased from 0.3 +/- 0.1 mg/kg to 3.0 +/- 1.0 mg/kg 5 min after injection of 250 micrograms DMA into the ligated upper small intestine. The disappearance curve of DMA in blood was monoexponential and the half-life for the initial 15 min was 12.5 min when 250 micrograms DMA were injected through a femoral vein. Intestinal secretion of DMA (15.6 +/- 12.6 mg/kg) was observed 15 min after the injection. Urinary DMA increased from 17.3 +/- 9.4 to 139 +/- 23 mg/kg within 30 min of intravenous injection of DMA. These results show that the behaviour of DMA in rats is as follows: (Formula: see text)
给Wistar雄性大鼠喂食含23.6毫克/千克二甲胺（DMA）的商业饲料，其胃肠道中DMA浓度在胃中最高（11.2±2.1毫克/千克），并从上段向下段降低。相比之下，喂食含1.0毫克/千克DMA的低DMA饲料的大鼠，上段小肠中DMA浓度最高（6.6±2.5毫克/千克）。在肠道中观察到DMA吸收，吸收曲线为单指数曲线。DMA在结扎胃、上段和下段小肠、盲肠和大肠中的生物半衰期（t1/2）分别为198、8.3、11.6、31.5和11.0分钟。向结扎的上段小肠注射250微克DMA后5分钟，血液中DMA浓度从0.3±0.1毫克/千克增加到3.0±1.0毫克/千克。当通过股静脉注射250微克DMA时，血液中DMA的消失曲线为单指数曲线，最初15分钟的半衰期为12.5分钟。注射后15分钟观察到肠道分泌DMA（15.6±12.6毫克/千克）。静脉注射DMA后30分钟内，尿中DMA从17.3±9.4增加到139±23毫克/千克。这些结果表明，DMA在大鼠体内的行为如下：（公式：见原文）
