Kabacoff B L, Douglass M L, Rosenberg I E, Levan L W, Punwar J K, Vielhuber S F, Lechner R J
IARC Sci Publ. 1984(57):347-52.
Nitrosation of water-soluble (diethanolamine) and oil-soluble (dodecylmethylamine and dicyclohexylamine) amines in the absence and presence of inhibitors in model anionic and non-ionic emulsions was studied. Nitrosation of diethanolamine occurred at similar rates in non-ionic and anionic emulsions. Surprisingly, dodecylmethylamine and dicyclohexylamine were readily nitrosated in non-ionic emulsions, but not in anionic emulsions. Sodium bisulfite and ascorbyl palmitate were effective inhibitors, but the activity of ascorbic acid was lower. Considerably less effective were potassium sorbate, alpha-tocopherol and butylated hydroxyanisole. The results of this study will help formulators of emulsion products to minimize N-nitrosamine contamination.
研究了在无抑制剂和有抑制剂存在的情况下，水溶性（二乙醇胺）和油溶性（十二烷基甲胺和二环己胺）胺类在模拟阴离子和非离子乳液中的亚硝化作用。二乙醇胺的亚硝化在非离子和阴离子乳液中的发生速率相似。令人惊讶的是，十二烷基甲胺和二环己胺在非离子乳液中易于亚硝化，但在阴离子乳液中则不然。亚硫酸氢钠和抗坏血酸棕榈酸酯是有效的抑制剂，但抗坏血酸的活性较低。山梨酸钾、α-生育酚和丁基羟基茴香醚的效果则要差得多。这项研究的结果将有助于乳液产品配方师将N-亚硝胺污染降至最低。
