Williams E D, Boddy K, Brown J J, Cumming A M, Davies D L, Harvey I R, Haywood J K, Lever A F, Robertson J I
J Hypertens. 1984 Apr;2(2):171-6. doi: 10.1097/00004872-198404000-00008.
The whole body content of sodium, potassium, chlorine, calcium, phosphorus and nitrogen was measured by neutron activation analysis in 13 patients with untreated primary hyperaldosteronism (Conn's syndrome; aldosterone-secreting adenoma). Concurrently, exchangeable sodium and potassium were estimated by isotope dilution. Results were compared with values in the same patients during treatment with potassium-conserving diuretics and again after removal of the adenoma; and also with those in a series of 30 patients having untreated essential hypertension. Both total body and exchangeable sodium were high in Conn's syndrome before treatment and were reduced by spironolactone or amiloride and by subsequent surgery. There was no evidence of alteration in the proportion of non-exchangeable sodium in this disease, in contrast to earlier reports. Total body and exchangeable potassium were low in untreated Conn's syndrome and increased to normal after therapy: the proportion of non-exchangeable potassium was similar before and after treatment, and also similar to that in essential hypertension. Total body chlorine was increased before treatment in Conn's syndrome and returned to normal with therapy; body calcium, phosphorus and nitrogen were normal throughout.
采用中子活化分析法对13例未经治疗的原发性醛固酮增多症（Conn综合征；醛固酮分泌腺瘤）患者的钠、钾、氯、钙、磷和氮的全身含量进行了测定。同时，通过同位素稀释法估算了可交换钠和钾。将结果与这些患者在使用保钾利尿剂治疗期间以及切除腺瘤后的数值进行了比较；还与30例未经治疗的原发性高血压患者的数值进行了比较。在Conn综合征患者中，治疗前全身钠和可交换钠均升高，螺内酯或氨氯吡咪治疗以及随后的手术可使其降低。与早期报告相反，没有证据表明该病中不可交换钠的比例发生改变。未经治疗的Conn综合征患者全身钾和可交换钾较低，治疗后升至正常：治疗前后不可交换钾的比例相似，也与原发性高血压患者的相似。Conn综合征患者治疗前全身氯升高，治疗后恢复正常；全身钙、磷和氮始终正常。
