Ransom R, Matela R J
J Embryol Exp Morphol. 1984 Nov;83 Suppl:233-59.
Development in multicellular animals consists of a constant progression of cell division, differentiation and morphogenesis. Our understanding of the relationship between division and the acquisition of shape and form is not well understood, and this paper describes a computer representation of cell division processes with possible applications to the modelling of developmental events. This representation is not itself a model in the true sense, but is a scaffolding onto which a set of model assumptions and parameters can be built. We discuss one such set of assumptions, used to model cell sorting, describe the extension of the framework to represent sheets of cells in three dimensions, and make some observations on the incorporation of mechanical forces into the representation.
多细胞动物的发育包括细胞分裂、分化和形态发生的持续进程。我们对细胞分裂与形状和形态形成之间关系的理解尚不充分，本文描述了一种细胞分裂过程的计算机表示形式，其可能应用于发育事件的建模。这种表示形式本身并非真正意义上的模型，而是一个可以构建一组模型假设和参数的框架。我们讨论了用于模拟细胞分选的一组这样的假设，描述了该框架扩展到三维表示细胞片层的情况，并对将机械力纳入该表示形式进行了一些观察。
