Pettibone D J, Kaufman N, Scally M C, Meyer E, Ulus I, Lytle L D
Science. 1978 Jun 9;200(4346):1175-7. doi: 10.1126/science.653362.
Intracaudate injections of kainic acid destroy striatal neurons containing acetylcholine and gamma-aminobutyric acid but leave dopaminergic nerve terminals in this brain region intact. Rats injected with the drug are aphagic and adipsic, and have other behavioral abnormalities strikingly similar to those seen in animals with lesions in the dopaminergic nigrostriatal bundle.
向尾状核内注射海藻酸会破坏含有乙酰胆碱和γ-氨基丁酸的纹状体神经元，但该脑区的多巴胺能神经末梢保持完整。注射了这种药物的大鼠会出现摄食和饮水减少的症状，并且还有其他行为异常，这些异常与多巴胺能黑质纹状体束受损的动物所表现出的症状极为相似。
