Olejniczak E, Lee H J
Steroids. 1984 Jun;43(6):657-62. doi: 10.1016/0039-128x(84)90028-x.
The systemic activities of methyl prednisolonate and methyl 17-deoxyprednisolonate (1) were studied in rats. Methyl 17-deoxyprednisolonate produced significant changes in the amount of sodium ion (decreased) and potassium ion (increased) in urine; however, methyl prednisolonate had no effect on electrolyte balance. Both methyl prednisolonate and methyl 17-deoxyprednisolonate had no effect on liver glycogen content, plasma corticosterone level and relative adrenal weight. In contrast, the parent compound prednisolone caused a significant decrease in liver glycogen content, plasma corticosterone level and relative adrenal weight.
在大鼠中研究了甲基泼尼松龙和17-脱氧甲基泼尼松龙（1）的全身活性。17-脱氧甲基泼尼松龙使尿中钠离子量（减少）和钾离子量（增加）产生显著变化；然而，甲基泼尼松龙对电解质平衡没有影响。甲基泼尼松龙和17-脱氧甲基泼尼松龙对肝糖原含量、血浆皮质酮水平和相对肾上腺重量均无影响。相比之下，母体化合物泼尼松龙导致肝糖原含量、血浆皮质酮水平和相对肾上腺重量显著降低。
