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根据小肠隐窝中碱性磷酸酶活性的变化以及细胞中3H-胸腺嘧啶核苷掺入程度来估计小肠在受到X射线和中子束照射后的再生情况。

Regeneration in small intestine following exposure to X-radiation and neutron beam as estimated in the light of changes in alkaline phosphatase activity and degree of 3H-thymidine incorporation into cells in intestinal crypts.

作者信息

Meyer-Brodniewicz J, Petruczenko A, Gnatowski B, Bałtrukiewicz Z

出版信息

Acta Physiol Pol. 1984 Jan-Feb;35(1):115-21.

PMID:6534077
Abstract

Swiss mice were irradiated with X-rays (5, 7 and 9 Gy) and neutrons (3 and 5 Gy) determining the degree of 3H-thymidine incorporation into the cells in the intestinal crypts, alkaline phosphatase activity in intestinal homogenate and serum, and radiation-induced leucopenia. It was shown that damage to the cells in intestinal crypts depends on the dose and type of radiation. More radiation-resistant cells covering the intestinal villi showed a significant inhibition of alkaline phosphatase activity at high radiation doses. Changes in intestinal alkaline phosphatase activity were reflected also by changes in its level in the serum where its dependence on the dose of radiation was evident also.

摘要

用X射线（5、7和9戈瑞）和中子（3和5戈瑞）照射瑞士小鼠，测定3H-胸腺嘧啶核苷掺入肠隐窝细胞的程度、肠匀浆和血清中的碱性磷酸酶活性以及辐射诱导的白细胞减少。结果表明，肠隐窝细胞的损伤取决于辐射剂量和类型。覆盖肠绒毛的更具辐射抗性的细胞在高辐射剂量下碱性磷酸酶活性受到显著抑制。血清中碱性磷酸酶水平的变化也反映了肠碱性磷酸酶活性的变化，其对辐射剂量的依赖性也很明显。

相似文献

1
Regeneration in small intestine following exposure to X-radiation and neutron beam as estimated in the light of changes in alkaline phosphatase activity and degree of 3H-thymidine incorporation into cells in intestinal crypts.根据小肠隐窝中碱性磷酸酶活性的变化以及细胞中3H-胸腺嘧啶核苷掺入程度来估计小肠在受到X射线和中子束照射后的再生情况。
Acta Physiol Pol. 1984 Jan-Feb;35(1):115-21.
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