Buzdar A U, Blumenschein G R
Cancer Treat Rev. 1984 Dec;11(4):315-9. doi: 10.1016/0305-7372(84)90031-8.
If generalizations can be drawn from these two sessions, we would suggest that evidence can be seen in support of certain principles for the chemotherapy of breast cancer. These principles are: Combination chemotherapy. Doxorubicin-containing combinations are superior to others in terms of improved remission rates. In the past decade, combination chemotherapy has resulted in significant improvement of survival in patients with disseminated breast cancer, and with this approach a small fraction of patients with metastatic disease have remained in extended complete remission. Dose of drugs. Drug combinations utilized at lower doses result in lower response rates. Drug dose rate. When chemotherapy is interrupted for treatment of local disease in inflammatory carcinoma of the breast, the survival rate of patients is lower compared to the subgroups of patients where there is no interruption in the treatment.
如果可以从这两次会议中得出一般性结论，我们建议可以看到支持乳腺癌化疗某些原则的证据。这些原则是：联合化疗。含阿霉素的联合化疗在提高缓解率方面优于其他化疗方案。在过去十年中，联合化疗显著提高了播散性乳腺癌患者的生存率，采用这种方法，一小部分转移性疾病患者实现了长期完全缓解。药物剂量。低剂量使用的联合药物导致较低的缓解率。给药速率。当在炎性乳腺癌中为治疗局部疾病而中断化疗时，与未中断治疗的患者亚组相比，患者的生存率较低。
