噻氯匹定作为血小板抗聚集剂抗镰变作用模型的体外研究
In vitro study of ticlopidine, as a model of antisickling action of platelet antiaggregant.
作者信息
Sablayrolles M, Wajcman H, Castaigne J P, Labie D
出版信息
Haematologia (Budap). 1984;17(2):199-207.
PMID:6534828
Abstract
The in vitro antisickling effect of ticlopidine may be explained by the action of the drug on the membrane. The drug molecule increases slightly the volume of the cell, decreases the mean intra-erythrocytic hemoglobin concentration and therefore affects the delay time for hemoglobin S polymerization.
摘要
噻氯匹定的体外抗镰状化作用可能是由该药物对细胞膜的作用来解释的。药物分子会使细胞体积略有增加，降低红细胞内血红蛋白的平均浓度，因此会影响血红蛋白S聚合的延迟时间。
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