Gleich G J, Schroeter A L, Marcoux J P, Sachs M I, O'Connell E J, Kohler P F
Trans Assoc Am Physicians. 1984;97:25-32.
Four patients with recurrent attacks of angioedema, urticaria, and fever were seen. During attacks, body weights increased up to 18% and leukocyte counts reached 108,000/microliters (88% eosinophils). Glucocorticoid therapy caused defervescence, diuresis, and decreased total leukocyte and eosinophil counts. The two children received prednisone intermittently; the adults did not require treatment or their conditions were controlled by alternate-day prednisone administration. No patient had evidence of cardiac involvement (follow-up, 2-17 years). The disease does not threaten the function of vital organs. One patient remained in spontaneous remission for 20 years before symptoms recurred. Although it might be classified as a variant of the hypereosinophilic syndrome, we believe that this syndrome is a separate entity because of its distinctive characteristics and its benign course.
我们观察了4例复发性血管性水肿、荨麻疹和发热患者。发作期间，体重增加高达18%，白细胞计数达到108,000/微升（88%为嗜酸性粒细胞）。糖皮质激素治疗导致退热、利尿，并使白细胞总数和嗜酸性粒细胞计数下降。两名儿童间歇性接受泼尼松治疗；成人无需治疗或通过隔日给予泼尼松控制病情。所有患者均无心脏受累证据（随访2 - 17年）。该疾病不威胁重要器官功能。1例患者在症状复发前自发缓解了20年。尽管它可能被归类为高嗜酸性粒细胞综合征的一种变体，但由于其独特的特征和良性病程，我们认为该综合征是一个独立的实体。
