Fonio de Gijón T, Amarillo H, Japaze H
Acta Gastroenterol Latinoam. 1984;14(2):155-9.
A retrospective study of 118 cases of haemorrhoids (77 cases), fissures (7 cases) and fistulas (34 cases) was done to demonstrate epithelial changes in each of the three microscopic components (transitional, rectal mucosa and keratinized squamous epithelium) of the anal canal. Histopathologically the three main lesion were metaplasia (16.9%), dysplasia (13.5%) and Koilocytotic changes (11.8%). On the other hand, the metaplastic lesion was found only on the rectal mucosa (100%), dysplasia was demonstrated on the rectal mucosa (9.8%) and on the transitional zone (21.5%). Finally koilocytosis was diagnosed only on the anal skin. The authors believe that the histopathology study (biopsy) is the best choice for the establishment of the preneoplastic lesions (dysplasia) in terms of an early detection of malignancy on the anal canal.
对118例痔疮（77例）、肛裂（7例）和肛瘘（34例）进行了一项回顾性研究，以证明肛管三个微观组成部分（移行部、直肠黏膜和角化鳞状上皮）中的上皮变化。组织病理学上，三种主要病变为化生（16.9%）、发育异常（13.5%）和挖空细胞改变（11.8%）。另一方面，化生病变仅见于直肠黏膜（100%），发育异常见于直肠黏膜（9.8%）和移行区（21.5%）。最后，挖空细胞改变仅在肛门皮肤处被诊断出来。作者认为，就早期发现肛管恶性肿瘤而言，组织病理学研究（活检）是确定癌前病变（发育异常）的最佳选择。
