Karppanen H
Ann Clin Res. 1984;16 Suppl 43:62-6.
The purpose of the present study was to test the hypothesis that an increased digitalis-like activity, induced by excessive intake of Na, is involved in the development and maintenance of hypertension. In normotensive rats prolonged administration of digitoxin alone induced only a mild and transient rise of blood pressure. Increased intake of NaCl did not affect the blood pressure of these rats. However, simultaneous administration of both digitoxin and NaCl produced a sustained elevation of blood pressure. In SHR the effect of the addition (6% of the weight of the pellets) of 1) NaCl or 2) a mixture containing 50% NaCl and 50% KCl or 3) a mixture containing 65% NaCl, 25% KCl, and 10% MgSO . 7H2O, was examined. A marked fall of blood pressure occurred during the use of the mixtures containing K and Mg. The results suggests that both an increased intake of Na and an increased digitalis-like activity are needed for the development of hypertension. The results on SHR confirm the previous findings demonstrating that the use of salt mixtures in which a part of the NaCl is replaced by K and Mg salts is beneficial compared to the use of NaCl. Furthermore, since K and Mg are effective antagonists of digitalis the results could suggest the involvement of an increased digitalis-like activity in the maintenance of hypertension.
过量摄入钠所诱导的洋地黄样活性增加与高血压的发生和维持有关。在正常血压大鼠中，单独长期给予洋地黄毒苷仅引起血压轻度短暂升高。增加氯化钠摄入量对这些大鼠的血压没有影响。然而，同时给予洋地黄毒苷和氯化钠会导致血压持续升高。在自发性高血压大鼠（SHR）中，研究了添加1）氯化钠或2）含50%氯化钠和50%氯化钾的混合物或3）含65%氯化钠、25%氯化钾和10%硫酸镁·7水合物（占颗粒重量的6%）的效果。使用含钾和镁的混合物期间，血压显著下降。结果表明，高血压的发生既需要钠摄入量增加，也需要洋地黄样活性增加。对自发性高血压大鼠的研究结果证实了先前的发现，即与使用氯化钠相比，使用部分氯化钠被钾盐和镁盐替代的盐混合物是有益的。此外，由于钾和镁是洋地黄的有效拮抗剂，这些结果可能表明洋地黄样活性增加与高血压的维持有关。
