Nielsen K, Teglbjaerg P S
Tumour Biol. 1984;5(6):313-20.
The occurrence and localization of CEA in mucosa of 15 gastric specimens removed because of adenocarcinoma and 12 gastric specimens removed because of benign ulcer were investigated. CEA occurred in nearly all foci of intestinal metaplasia of the "colonic type" characterized by the secretion of O-acetylated sialo-mucins. In intestinal metaplasia characterized by secretion of sulphomucin a few foci contained CEA. "Small intestinal type" metaplasia, characterized by secretion of non-sulphated acid mucins, and normal gastric epithelium did not contain CEA. These findings may explain some of the discrepancies of earlier published work on the CEA content of intestinal metaplasia. The correlation between CEA and intestinal metaplasia of the "colonic type", known to be associated with gastric adenocarcinoma, may identify a special type of intestinal metaplasia which could be important in the histogenesis of certain types of gastric carcinoma.
对15例因腺癌而切除的胃标本及12例因良性溃疡而切除的胃标本的黏膜中癌胚抗原（CEA）的发生及定位进行了研究。CEA几乎出现在所有以分泌O - 乙酰化唾液粘蛋白为特征的“结肠型”肠化生灶中。在以分泌硫酸粘蛋白为特征的肠化生中，少数病灶含有CEA。以分泌非硫酸化酸性粘蛋白为特征的“小肠型”化生及正常胃上皮不含CEA。这些发现可能解释了早期发表的关于肠化生CEA含量的一些研究结果的差异。已知与胃腺癌相关的CEA与“结肠型”肠化生之间的相关性，可能识别出一种特殊类型的肠化生，这在某些类型胃癌的组织发生中可能很重要。
