苯巴比妥对大鼠N-双（2-羟丙基）亚硝胺甲状腺肿瘤发生的促进作用。不同暴露时长的苯巴比妥的影响。

Promoting effect of phenobarbital on N-bis (2-hydroxypropyl)nitrosamine thyroid tumorigenesis in rats. Effect of varying duration of exposure to phenobarbital.

作者信息

Hiasa Y, Kitahori Y, Konishi N, Enoki N, Fujita T

出版信息

IARC Sci Publ. 1984(56):77-82.

Abstract

Male Wistar rats were injected subcutaneously with a single dose of 280 mg N-bis(2-hydroxypropyl)nitrosamine (DHPN) per 100 g body weight and then given a diet containing 500 mg/kg phenobarbital (PB) for 6, 12 and 19 weeks. Exposure to PB for 12 or 19 weeks enhanced the development of thyroid tumours in rats treated with DHPN. The incidences of thyroid tumours at the end of the experiment were 87% in rats given DHPN and then PB for 19 weeks, 83% in rats given DHPN and then PB for 12 weeks, 42% in rats given DHPN and then PB for 6 weeks, and 37% in rats given DHPN. The incidence of thyroid cancer was 12% in rats given DHPN and then PB for 19 weeks. The total numbers of thyroid tumours were: 241 in rats given DHPN and then PB for 19 weeks, 125 in rats given DHPN and then PB for 12 weeks, 65 in rats given DHPN and then PB for 6 weeks, and 23 in rats given DHPN alone. The total numbers of thyroid tumours were proportional to the period of exposure to PB.

摘要

将每100克体重280毫克的N-双（2-羟丙基）亚硝胺（DHPN）单剂量皮下注射给雄性Wistar大鼠，然后给予含500毫克/千克苯巴比妥（PB）的饮食，持续6、12和19周。用DHPN处理的大鼠，暴露于PB 12周或19周会增强甲状腺肿瘤的发生。实验结束时，先给予DHPN然后给予PB 19周的大鼠甲状腺肿瘤发生率为87%，先给予DHPN然后给予PB 12周的大鼠为83%，先给予DHPN然后给予PB 6周的大鼠为42%，仅给予DHPN的大鼠为37%。先给予DHPN然后给予PB 19周的大鼠甲状腺癌发生率为12%。甲状腺肿瘤总数分别为：先给予DHPN然后给予PB 19周的大鼠241个，先给予DHPN然后给予PB 12周的大鼠125个，先给予DHPN然后给予PB 6周的大鼠65个，仅给予DHPN的大鼠23个。甲状腺肿瘤总数与暴露于PB的时间成正比。