苯巴比妥和巴比妥对用N-双（2-羟丙基）亚硝胺处理的大鼠甲状腺肿瘤发生的促进作用
Promoting effects of phenobarbital and barbital on development of thyroid tumors in rats treated with N-bis(2-hydroxypropyl)nitrosamine.
作者信息
Hiasa Y, Kitahori Y, Ohshima M, Fujita T, Yuasa T, Konishi N, Miyashiro A
出版信息
Carcinogenesis. 1982;3(10):1187-90. doi: 10.1093/carcin/3.10.1187.
Phenobarbital (PB) and barbital (BB) promoted the development of thyroid tumors in rats treated with a sub-effective dose of N-bis(2-hydroxypropyl)nitrosamine (DHPN) for thyroid tumorigenesis. Rats were given s.c. injections of 70 mg DHPN/100 g body weight once a week for 4 or 6 weeks with or without diet containing 500 p.p.m. PB or BB for the next 12 weeks. The incidences of thyroid tumors at the end of week 20 of the experiment were 66% in rats given DHPN for 4 weeks and then PB, 23% in rats given DHPN for 4 weeks and then BB, 100% in rats given DHPN for 6 weeks and then PB, 45% in rats given DHPN for 6 weeks and then BB, and 23% in rats given DHPN for 6 weeks. Rats given only DHPN for 4 weeks or only PB or BB had no thyroid tumors after 20 weeks.
苯巴比妥（PB）和巴比妥（BB）促进了用亚有效剂量的N-双（2-羟丙基）亚硝胺（DHPN）进行甲状腺肿瘤诱发处理的大鼠甲状腺肿瘤的发展。大鼠每周皮下注射70毫克DHPN/100克体重，持续4或6周，在接下来的12周内，给予或不给予含500 ppm PB或BB的饮食。在实验第20周结束时，接受DHPN 4周然后PB的大鼠甲状腺肿瘤发生率为66%，接受DHPN 4周然后BB的大鼠为23%，接受DHPN 6周然后PB的大鼠为100%，接受DHPN 6周然后BB的大鼠为45%，接受DHPN 6周的大鼠为23%。仅接受DHPN 4周或仅接受PB或BB的大鼠在20周后没有甲状腺肿瘤。
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