Khantzian E J, Gawin F, Kleber H D, Riordan C E
J Subst Abuse Treat. 1984;1(2):107-12. doi: 10.1016/0740-5472(84)90033-3.
The authors report on three cases of cocaine dependence treated with methylphenidate. All patients treated showed marked to dramatic improvement with regard to toxic/abstinence signs and symptoms, craving behavior and other behavioral disturbances associated with heavy and chronic cocaine abuse. The authors explore the possibility that cocaine dependence is associated with pre-existing or resulting psychopathology, particularly mood disturbances. Emphasis is also placed on a predisposing or de novo attention deficit disorder (ADD) as possibly contributing to heavy or continued reliance on cocaine.
作者报告了三例使用哌醋甲酯治疗可卡因依赖的病例。所有接受治疗的患者在毒性/戒断体征和症状、渴望行为以及与重度和慢性可卡因滥用相关的其他行为障碍方面均有显著至巨大的改善。作者探讨了可卡因依赖与先前存在或由此导致的精神病理学，特别是情绪障碍相关的可能性。还强调了易患性或新发的注意力缺陷障碍（ADD）可能导致对可卡因的重度或持续依赖。
