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酒精中毒的血液学伴随症状:一种临床筛查技术的开发与验证

Hematological concomitants of alcoholism: development and validation of a clinical screening technique.

作者信息

Hawkins M R, Silsby H D, Kruzich D J, Sittig D R

出版信息

J Subst Abuse Treat. 1984;1(4):271-6. doi: 10.1016/0740-5472(84)90006-0.

Abstract

An investigation into the use of blood chemistry variables in the identification of young adult alcoholics revealed that a combinative process utilizing 11 blood chemistry variables was superior to the use of individual measures. The investigation further validated the use of a linear discriminant analysis technique in identifying the blood chemistry measures and a discriminant function was produced that classified alcoholics and controls with a high degree of accuracy. This level of precision in prediction was maintained in validation trials on independent samples. The blood chemistry variables were extracted from a combination of commonly ordered blood tests. Results of the investigation indicate that clinical usage of the screening procedure is readily available without sophisticated computer support or exotic blood analysis.

摘要

一项关于利用血液化学变量识别年轻成年酗酒者的调查显示,采用11种血液化学变量的组合方法优于单独使用各项指标。该调查进一步验证了线性判别分析技术在识别血液化学指标方面的应用,并生成了一个判别函数,该函数能够以高度的准确性对酗酒者和对照组进行分类。在对独立样本的验证试验中,预测的精度保持在这一水平。血液化学变量是从常用血液检测的组合中提取的。调查结果表明,该筛查程序在临床应用中无需复杂的计算机支持或特殊的血液分析即可轻松实现。

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