Katoh-Semba R, Kashiwamata S
Neurochem Pathol. 1984 Spring;2(1):31-7. doi: 10.1007/BF02834170.
The rates of protein synthesis and degradation, and the endogenous leucine content on days 13 and 30, were examined in the cerebellum of homozygous Gunn rats with cerebellar hypoplasia and compared with those of heterozygotes. The rate of protein synthesis based on milligrams of protein was significantly lower on day 30 and the degradation rate was about ten times faster between days 13 and 18. Furthermore, leucine concentration was about 1.7 times higher on day 13. The present results suggest that the lowered protein concentration previously observed in the cerebellum of homozygous Gunn rats is ascribed to the increased rate of protein degradation on day 13, and to the decreased rate of protein synthesis on day 30.
在患有小脑发育不全的纯合子Gunn大鼠的小脑中，检测了第13天和第30天的蛋白质合成和降解速率以及内源性亮氨酸含量，并与杂合子进行了比较。以蛋白质毫克数为基础的蛋白质合成速率在第30天显著降低，降解速率在第13天至第18天之间快约10倍。此外，第13天亮氨酸浓度约高1.7倍。目前的结果表明，先前在纯合子Gunn大鼠小脑中观察到的蛋白质浓度降低归因于第13天蛋白质降解速率的增加，以及第30天蛋白质合成速率的降低。
