一些6β-乙酰硫基羟基甾体的合成。
Synthesis of some 6 beta-acetylthio hydroxysteroids.
作者信息
Pouskouleli G, Butler I S
出版信息
Steroids. 1984 Aug;44(2):123-36. doi: 10.1016/s0039-128x(84)90067-9.
PMID:6537048
Abstract
The reactions of 3 beta-hydroxy-20-oxo-5-pregnene-16 alpha-carbonitrile, 3 beta-hydroxy-5-androsten-17-one, 3 beta-hydroxy-5-pregnen-20-one, and 5-cholesten-3 beta-ol with thioacetic acid in dioxane afford mainly 6 beta-acetylthio derivatives which were characterized by IR, NMR (1H, 13C), and mass spectroscopy. A similar reaction of 17 beta-hydroxy-1,4-androstadien-3-one yields chiefly the known 1 alpha-SCOCH3 derivative.
摘要
3β-羟基-20-氧代-5-孕烯-16α-腈、3β-羟基-5-雄甾烯-17-酮、3β-羟基-5-孕烯-20-酮和5-胆甾烯-3β-醇与硫代乙酸在二氧六环中的反应主要生成6β-乙酰硫基衍生物，这些衍生物通过红外光谱、核磁共振（1H、13C）和质谱进行了表征。17β-羟基-1,4-雄甾二烯-3-酮的类似反应主要生成已知的1α-SCOCH3衍生物。
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