Di Gregorio C, Fano R A, Criscuolo M
Appl Pathol. 1984;2(2):110-5.
A case of melanotic schwannoma of the sacral region, studied with electron microscopy and immunohistochemistry, is reported. Melanosomes in all stages of formation were ultrastructurally demonstrable in neoplastic cells, which showed prominent basal lamina and interdigitating cytoplasmic processes. These findings support the Schwann cell origin of the tumor and indicate that Schwann cells are capable of melanin production. The immunohistologic examination showed the absence of neoplastic cells for all antigens tested (S-100 protein, glial fibrillary acidic protein, lysozyme, alpha 1-antitrypsin, alpha 1-antichimotrypsin, keratin). Apart from questioning the nature of the tumor, S-100 protein absence could raise doubts on its benign course. In the reported case, no local recurrence or distant metastases have been recorded 2 years after surgery.
报告了一例经电子显微镜和免疫组织化学研究的骶骨区域黑色素性神经鞘瘤。在肿瘤细胞中可超微结构显示处于各个形成阶段的黑素小体，这些细胞显示出明显的基膜和相互交错的细胞质突起。这些发现支持肿瘤起源于雪旺细胞，并表明雪旺细胞能够产生黑色素。免疫组织学检查显示，所有检测的抗原（S-100蛋白、胶质纤维酸性蛋白、溶菌酶、α1-抗胰蛋白酶、α1-抗糜蛋白酶、角蛋白）的肿瘤细胞均为阴性。除了质疑肿瘤的性质外，S-100蛋白阴性可能会对其良性病程产生怀疑。在报告的病例中，术后2年未记录到局部复发或远处转移。
