Canbeyli R S, Koopmans H S
Physiol Behav. 1984 Dec;33(6):945-50. doi: 10.1016/0031-9384(84)90234-8.
The significance of the upper small intestine in long-term regulation of food intake was investigated in pairs of parabiotic rats in which a 30 cm transected segment of each rat's intestine was sewn into continuity with the intestine of its partner. In this preparation, food eaten by one rat passes through its own stomach and 5 cm of its duodenum and then moves into the partner's intestine. The food traverses the 30 cm segment of the partner's intestine before returning to its own lower small intestine. All pairs were fed a liquid diet 11 hr/day. When the regular diet was diluted 1:1 with water, all rats showed a significant, nearly compensatory increase in their daily intake. In contrast, when only one rat in each pair was fed, thereby depriving it of intrajejunal input from its fasted partner, there was no significant increase in its food intake for about six days, followed by a gradual increase which was never fully compensatory as shown by continued loss of weight for the pair. Feeding rats could not be trained to notice the loss of intrajejunal input by making such loss coincident with a change in diet flavor. Jejunal satiety cues arising from a 30 cm segment, if they exist, do not seem to play a significant role in long-term regulation of food intake.
通过联体大鼠研究了上段小肠在食物摄入量长期调节中的作用。在联体大鼠中，将每只大鼠30厘米长的一段横断小肠与同伴的小肠缝合在一起。在这种制备方法中，一只大鼠吃的食物会经过它自己的胃和5厘米的十二指肠，然后进入同伴的小肠。食物在回到自身下段小肠之前，会穿过同伴小肠的30厘米段。所有联体大鼠每天11小时喂食流质饮食。当常规饮食用水1:1稀释时，所有大鼠的日摄入量都显著增加，且几乎呈代偿性增加。相反，当每对联体大鼠中只有一只喂食，从而使其得不到禁食同伴的空肠内输入时，其食物摄入量在大约六天内没有显著增加，随后逐渐增加，但从未完全代偿，这对大鼠持续体重减轻就说明了这一点。无法通过使空肠内输入的缺失与饮食味道的变化同时出现，来训练喂食大鼠注意到空肠内输入的缺失。如果存在来自30厘米段的空肠饱腹感信号，它们似乎在食物摄入量的长期调节中并不起重要作用。
