Department of Psychiatry, University of British Columbia, Vancouver, V6T 2A1, Canada.
Behav Brain Res. 2012 Jun 1;231(2):279-85. doi: 10.1016/j.bbr.2012.02.017. Epub 2012 Feb 17.
The relationship between food restriction and subsequent dysregulation of food intake is complex, variable and long-lasting. The present study investigated in rats whether repeated cycles of food restriction and binge feeding opportunities may alter regulation of food intake by employing a test for sensory-specific satiety. Rats that experienced repeated food restriction-binge cycles maintained heavier body weights compared to rats that remained on continuous food restriction. In contrast to the control subjects, rats that alternated between food restriction and binge feeding failed to display sensory-specific satiety. During the first meal, there was a gradual decrease in the amount of food intake over a 40 min period. When presented with a second meal of the same food, these rats responded to the familiar food in a manner similar as to a novel food (i.e., comparable quantities of both types of food were consumed). Food restriction-binge feeding cycles may be considered as a form of stress, which in turn is associated with cross-sensitization to numerous behavioral responses. Therefore, we propose that stress-induced disruption of sensory-specific satiety reflects a sensitized response to food, in which the interaction between sensory and satiety factors are no longer the key regulators of food choice and meal cessation. Furthermore, a role for sensory-specific satiety in terminating food intake appeared to decline with the progression of the cycles, thereby contributing to a steady increase in body weight of rats that experienced restriction with bouts of binge feeding opportunities.
食物限制与随后的食物摄入失调之间的关系是复杂的、多变的且持久的。本研究通过采用感官特异性饱食测试，在大鼠中探讨了反复的食物限制-暴食循环是否会改变食物摄入的调节。与持续食物限制的大鼠相比，经历反复食物限制-暴食循环的大鼠体重更重。与对照组大鼠不同，在食物限制和暴食之间交替的大鼠未能表现出感官特异性饱食。在第一餐中，在 40 分钟的时间内，食物摄入量逐渐减少。当给予相同食物的第二餐时，这些大鼠对熟悉的食物的反应方式与对新食物的反应方式相似（即，两种类型的食物的摄入量相当）。食物限制-暴食循环可以被认为是一种压力形式，而压力又与对多种行为反应的交叉敏感有关。因此，我们提出，应激引起的感官特异性饱食中断反映了对食物的敏感反应，其中感觉和饱腹感因素之间的相互作用不再是食物选择和进食停止的关键调节因素。此外，感官特异性饱食在终止食物摄入中的作用似乎随着循环的进展而下降，从而导致经历限制和暴食机会的大鼠体重稳步增加。
