体内尾蚴-童虫转化：奥沙尼喹的抑制作用
In vivo cercaria-schistosomulum transformation: inhibitory effect of oxamniquine.
作者信息
Melo A L, Pereira L H, Corrêa C R
出版信息
Trans R Soc Trop Med Hyg. 1978;72(2):158-9. doi: 10.1016/0035-9203(78)90051-2.
High doses of oxamniquine (given intramuscularly) produced inhibition of cercaria-schistosomulum transformation following intraperitoneal injections of cercariae into mice. Cercariae, tail-less cercarial bodies, and schistosomula were recovered from the peritoneal cavity of drug-treated mice in numbers significantly different from those recovered from untreated mice. Since untreated animals induced transformation of almost all the injected cercariae, the data suggest the compound is active during the process of host-larvae adaptation.
高剂量的奥沙尼喹（肌肉注射给药）在向小鼠腹腔内注射尾蚴后，可抑制尾蚴-血吸虫幼虫转化。从药物处理小鼠的腹腔中回收的尾蚴、无尾尾蚴体和血吸虫幼虫数量与从未处理小鼠中回收的数量有显著差异。由于未处理的动物几乎能使所有注射的尾蚴发生转化，这些数据表明该化合物在宿主-幼虫适应过程中具有活性。
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