Monichev A Ia, Gruzdev G P
Tsitologiia. 1978;20(1):117-20.
Various methods of commitment regulation have been analysed on the basis of the mathematical model of the haemopoietic stem cell number dynamics. The starting point is the requirement on the system stability. The basic hypothesis is that of the intrinsic nature of the population commitment regulation. The analysis states that the commitment specific velocity increases with stem cell number. This way of regulation may be performed in the case the commitment takes place at Go phase of the cell cycle. The role of the committed precursor pool in providing the haemopoietic system reliability is discussed.
