人类中多基因上位性相互作用的证据？
Evidence for polygenic epistatic interactions in man?
作者信息
Heath A C, Martin N G, Eaves L J, Loesch D
出版信息
Genetics. 1984 Apr;106(4):719-27. doi: 10.1093/genetics/106.4.719.
Abstract
Studies of multifactorial inheritance in man have ignored nonadditive gene action or attributed it entirely to dominance. Reanalyses of dermatoglyphic data on monozygotic and dizygotic twins, siblings and parents and offspring suggest that a substantial proportion of variation in total finger pattern intensity is due to epistatic interactions between additive genetic deviations, not dominance. Bootstrapping and power simulations support this interpretation of the data. We believe this is the strongest evidence so far for polygenic epistasis in man.
摘要
对人类多因素遗传的研究忽略了非加性基因作用，或者将其完全归因于显性。对同卵双胞胎、异卵双胞胎、兄弟姐妹以及父母与后代的皮纹数据进行重新分析表明，总指纹图案强度的很大一部分变异是由于加性遗传偏差之间的上位性相互作用，而非显性。自展法和功效模拟支持了对这些数据的这一解释。我们认为这是目前人类多基因上位性的最有力证据。
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