Sydorenko N P
J Muscle Res Cell Motil. 1984 Apr;5(2):117-29. doi: 10.1007/BF00712151.
A model of a two-headed myosin crossbridge, whose motion is realized by alternate stepping of its two heads on two actin filaments, is proposed. The geometrical possibility of such crossbridge stepping in contracting skeletal muscle is shown, provided that a free myosin head can bind to an actin filament at a right angle and the attached one can tilt to a greater angle than 45 degrees. Motion of a myosin-like protein along actin filaments in Characean alga cells can proceed by a similar mechanism.
提出了一种双头肌球蛋白横桥模型，其运动是通过两个头部在两条肌动蛋白丝上交替迈步来实现的。结果表明，在收缩的骨骼肌中，这种横桥迈步在几何上是可能的，前提是一个游离的肌球蛋白头部可以以直角与肌动蛋白丝结合，而附着的头部可以倾斜到大于45度的角度。轮藻细胞中类肌球蛋白蛋白沿肌动蛋白丝的运动可能通过类似的机制进行。
