Ramirez-Lassepas M, Cipolle R J, Rodvold K A, Seifert R D, Strand L, Taddeini L, Cusulos M
Neurology. 1984 Jun;34(6):736-40. doi: 10.1212/wnl.34.6.736.
We studied 137 patients who were treated with heparin for cerebral infarction (73), partially reversible ischemic neurologic deficit (22), or transient ischemic attack (42). Platelet counts were performed before therapy, twice weekly, and at cessation of therapy. Platelets decreased in 118 patients (86%). In 21 (15.3%), platelets dropped greater than or equal to 40%; 9 of 14 new ischemic events and three of six deaths occurred in this group of patients. Because there was a significant association between poor outcome and platelet drop greater than or equal to 40% (p less than 0.001), we believe that platelets should be monitored frequently when patients are treated with heparin for ischemic cerebrovascular disease.
我们研究了137例接受肝素治疗的患者，这些患者患有脑梗死（73例）、部分可逆性缺血性神经功能缺损（22例）或短暂性脑缺血发作（42例）。在治疗前、每周两次以及治疗结束时进行血小板计数。118例患者（86%）血小板减少。21例（15.3%）患者血小板下降大于或等于40%；14例新的缺血性事件中的9例以及6例死亡中的3例发生在这组患者中。由于不良预后与血小板下降大于或等于40%之间存在显著关联（p小于0.001），我们认为，当患者因缺血性脑血管疾病接受肝素治疗时，应频繁监测血小板。
