Wood J H, Polyzoidis K S, Epstein C M, Gibby G L, Tindall G T
Neurology. 1984 Jun;34(6):764-8. doi: 10.1212/wnl.34.6.764.
Eleven patients with ischemic neurologic deficits in the middle cerebral arterial (MCA) territory and ipsilateral slowing on initial EEG underwent venesection and equal volume replacement with intravenous 5% human serum albumin. As the mean hematocrit was reduced by 19%, the mean cerebral blood flow (CBF) in the MCA territory of the affected and contralateral hemisphere determined by the 133Xenon inhalation technique increased 18 and 21%, respectively. Similarly, CBF in the contralateral occipital region increased 17%. The percentage total slow-wave EEG activity (fractional sum of theta and delta activity, 1.0 to 7.5 Hz) determined by fourier analysis was reduced significantly in the affected MCA territory and in the contralateral occipital region within 1 to 2 hours after isovolemic hemodilution. Using quantitative EEG analysis, rapid improvement in background EEG activity can be demonstrated following the diffuse elevation in CBF by hemodilution.
11例大脑中动脉（MCA）供血区出现缺血性神经功能缺损且初始脑电图显示同侧脑电活动减慢的患者接受了静脉放血，并通过静脉注射5%人血清白蛋白进行等量置换。随着平均血细胞比容降低19%，采用氙133吸入技术测定的患侧半球和对侧半球MCA供血区的平均脑血流量（CBF）分别增加了18%和21%。同样，对侧枕叶区域的脑血流量增加了17%。通过傅里叶分析确定的总慢波脑电图活动百分比（θ波和δ波活动的分数总和，1.0至7.5赫兹）在等容血液稀释后1至2小时内，在患侧MCA供血区和对侧枕叶区域显著降低。使用定量脑电图分析，可以证明在血液稀释导致脑血流量普遍升高后，背景脑电图活动会迅速改善。
