Mepham T B, Lawrence S E, Peters A R, Hart I C
Horm Metab Res. 1984 May;16(5):248-53. doi: 10.1055/s-2007-1014757.
The galactopoietic effect of daily injections, for five day periods, of growth hormone was examined by measuring milk yield, mammary blood flow and arteriovenous differences of glucose and amino acids on 12 occasions in four goats. In 10 periods there were marked increases (mean 18.1%) in mammary blood flow (8 statistically significant) and less-marked increases (mean 8.0%) in milk yield (6 statistically significant). On 8 of the occasions on which it was measured the maximum blood plasma growth hormone concentration was increased to more than 8 ng/ml. There were no statistically significant changes in mammary arteriovenous concentration differences of glucose or amino acids in response to growth hormone injections. It is suggested that, contrary to the usual situation in which the rate of mammary blood flow appears to be regulated by the metabolic activity of the gland, the galactopoietic response to growth hormone may be a consequence of elevated blood flow, which increases the supply to the gland of rate-limiting metabolic substrates.
通过对四只山羊进行12次测量，分别测定产奶量、乳腺血流量以及葡萄糖和氨基酸的动静脉差异，研究了连续五天每日注射生长激素的催乳作用。在10个时间段中，乳腺血流量显著增加（平均增加18.1%，8次具有统计学意义），产奶量增加幅度较小（平均增加8.0%，6次具有统计学意义）。在8次测量中，血浆生长激素最大浓度增加至8 ng/ml以上。注射生长激素后，乳腺葡萄糖或氨基酸的动静脉浓度差异无统计学意义的变化。有人提出，与通常情况下乳腺血流量似乎由腺体代谢活动调节的情况相反，生长激素的催乳反应可能是血流量增加的结果，血流量增加会增加对腺体限速代谢底物的供应。
